Distribution, design characteristics, and dissemination of clinical trials by funding organisation and medical specialty

Data for 45,620 clinical trials were downloaded from ClinicalTrials.gov and categorised by design characteristics (as a marker of methodological quality), funder type and disease area, and linked to disclosed study results. In an accompanying commentary by the first author, Magdalena Zwierzyna writes: “We found that trial phase, size, design, and even medical specialty all associate with the likelihood of trial publication in medical journals.  One thing is for certain: the evidence available in scientific literature is largely incomplete, and could well be distorted as well.”


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