Distribution, design characteristics, and dissemination of clinical trials by funding organisation and medical specialty

Data for 45,620 clinical trials were downloaded from ClinicalTrials.gov and categorised by design characteristics (as a marker of methodological quality), funder type and disease area, and linked to disclosed study results. In an accompanying commentary by the first author, Magdalena

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Research in Palestine shows mismatch with burden of disease and inadequate reporting

Several studies have shown a mismatch between ‘Burden of Disease and research funding in developed countries. But the problem appears to be near universal. This study reviewed 511 studies from Palestine. It found that research output was poorly associated with

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Some drug companies unwilling to share unredacted trial protocols

A study has found that half of drug company trial protocols have information deleted from key sections of the protocol, with the extent of redactions often so vast as to render the protocol useless for identifying discrepancies with subsequent publications.

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Major UK Funder SWATs waste in research

Health related research is impressive; it changes lives and it saves lives. It is a collective endeavour by people committed to making a difference to patients and the public. It is also a complicated endeavour. One that involves a number

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New audit of non-commercial funders’ policies

A new audit of non-commercial funders’ policies has been published in JAMA by Ben Goldacre’s team at the EBMDataLab at the University of Oxford. Out of 18 charities and federal bodies, which between them spend around $40 billion on health research every year, the researchers

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Non-publication rates by US Institutions

A recent investigation of publication rates found that most US research institutions — including leading universities and hospitals in addition to drug companies — routinely break a US law that requires them to report the results of human studies of

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A history of the evolution of guidelines for reporting medical research: the long road to the EQUATOR Network

A history of the evolution of guidelines for reporting medical research: the long road to the EQUATOR Network. « The James Lind Library Introduction Testing medical treatments and other interventions aimed at improving people’s health is incredibly important. However, comparative

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Mona Nasser: How can research publication be improved?

The first day of the EQUATOR/REWARD conference coincided with the publication of the most recent article on reducing waste in research—“increasing value and reducing waste in biomedical research: who’s listening?” The paper explores how different stakeholders responded to the call

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The Need for Randomisation in Animal Trials

Randomisation, allocation concealment and blind outcome assessment have been shown to reduce bias in human trials and have been used for over four decades to improve the quality of clinical trials. For animal studies, this has not been thoroughly investigated and

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Reducing waste in preclinical research through better mouse studies

Increasing value and reducing waste in research has to start at the pre-clinical stage, with high quality animal studies and well-characterised mouse models of disease. Steve Perrin provides recommendations for researchers to “make mouse studies work” in a comment in

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